saquinavir |
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| • | Saquinavir (Fortovase®, Roche) is a protease inhibitor, used as a component of HIV therapy. Saquinavir mesylate (Invirase®, Roche) is a different formulation, designed to be combined with another protease inhibitor that increases the bioavailability of the saquinavir. When given alone the HIV Protease Inhibitor (HPI) saquinavir has a very low oral bioavailability. In the clinic it was found that when patients also received the HPI ritonavir the oral bioavailability of saquinavir significantly increases. For patients this has the major benefit that they can take less saquinavir, while maintaining sufficient saquinavir blood plasma levels to efficiently suppress the replication of HIV. The mechanism behind this welcome observation was not directly known, but later it was determined that ritonavir inhibits the enzym Cytochrome P450 3A4. Normally, this enzym metabolized saquinavir to an inactive form and with the ritonavir inhibiting this enzym the saquinavir blood plasma levels increased considerably. Additionally, ritonavir also inhibits multidrug transporters, although to a much lower extent. Source: [wikipedia: saquinavir] |
drugs_and_medications:pharmacy
| Saquinavir (Fortovase) by Roche Laboratories, Inc. | ||
| a protease inhibitor soft gel cap used to treat hiv. site offers press releases, complete product information, and sections for patients and healthcare professionals. | ||
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