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Difino
| • | Andes virus (ANDV)Bayou virus (BAYV)Black Creek Canal virus (BCCV)Cano Delgadito virus (CADV)Dobrava-Belgrade virus (DOBV)El Moro Canyon virus (ELMCV)Hantaan virus (HTNV)Isla Vista virus (ISLAV)Khabarovsk virus (KHAV)Laguna Negra virus (LANV)Muleshoe virus (MULV)New York virus (NYV)Prospect Hill virus (PHV)Puumala virus (PUUV)Rio Mamore virus (RIOMV)Rio Segundo virus (RIOSV)Seoul virus (SEOV)Sin Nombre virus (SNV)Thailand virus (THAIV)Thottapalayam virus (TPMV)Topografov virus (TOPV)Tula virus (TULV)
Hantaviruses belong to the bunyavirus family of viruses. There are 5 genera within the bunyaviridae family: bunyavirus, phlebovirus, nairovirus, tospovirus, and hantavirus. Each is made up of negative-sensed, single-stranded RNA viruses. All these genera include arthropod-borne viruses, with the exception of hantavirus, which is rodent-borne.
Like other members of the bunyavirus family, hantaviruses are enveloped viruses with a genome that consists of three single-stranded RNA segments designated S (small), M (medium), and L (large). All hantaviral genes are encoded in the negative (genome complementary) sense. The S RNA encodes the nucleocapsid (N) protein. The M RNA encodes a polyprotein that is cotranslationally cleaved to yield the envelope glycoproteins G1 and G2. The L RNA encodes the L protein, which functions as the viral transcriptase/replicase. Within virions, the genomic RNAs of hantaviruses are thought to complex with the N protein to form helical nucleocapsids, which circularize due to sequence complementarity between the 5' and 3' terminal sequences of each genomic segment.
Hantaviruses replicate exclusively in the host cell cytoplasm. Entry into host cells is thought to occur by attachment of virions to cellular receptors and subsequent endocytosis. Nucleocapsids are introduced into the cytoplasm by pH-dependent fusion of the virion with the endosomal membrane. Transcription of viral genes is initiated by association of the L protein with the three nucleocapsid species. In addition to transcriptase and replicase functions, the viral L protein is also thought to have an endonuclease activity that cleaves cellular messen
Source: [wikipedia: hantavirus]
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